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CHRONIC KIDNEY DISEASE CAUSES
Causes of
Chronic Kidney Disease
Reflux
Nephropathy
Reflux nephropathy (a congenital and often inherited abnormality
of the vesicoureteric junction) and congenital structural
abnormalities of the urinary tract are important causes of
chronic kidney
disease
in the young, the mean age of entering
kidney
replacement therapy programmes being 30 years.
Once a threshold fraction of nephron mass has been lost, perhaps
as a consequence of infection-related scarring, the remaining
glomeruli develop segmental hyalinosis and eventually sclerosis,
manifesting as proteinuria and hypertension, both heralding a
steady decline towards end-stage disease. Antireflux procedures
make no difference to the prognosis, and management is medical.
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